Protein family classification and functional annotation
نویسندگان
چکیده
منابع مشابه
Protein family classification and functional annotation
With the accelerated accumulation of genomic sequence data, there is a pressing need to develop computational methods and advanced bioinformatics infrastructure for reliable and large-scale protein annotation and biological knowledge discovery. The Protein Information Resource (PIR) provides an integrated public resource of protein informatics to support genomic and proteomic research. PIR prod...
متن کاملFamily Classification and Integrative Analysis for Protein Functional Annotation
The high-throughput genome projects have resulted in a rapid accumulation of predicted protein sequences, however, experimentally-verified information on protein function lags far behind. The common approach to inferring function of uncharacterized proteins based on sequence similarity to annotated proteins in sequence databases often results in over-identification, underidentification, or even...
متن کاملA Family Classification Approach to Functional Annotation of Proteins
The high-throughput genome projects have resulted in a rapid accumulation of genome sequences for a large number of organisms. To fully realize the value of the data, scientists need to identify proteins encoded by these genomes and understand how these proteins function in making up a living cell. With experimentally verified information on protein function lagging far behind, computational me...
متن کاملPIRSF Family Classification System for Protein Functional and Evolutionary Analysis
The PIRSF protein classification system (http://pir.georgetown.edu/pirsf/) reflects evolutionary relationships of full-length proteins and domains. The primary PIRSF classification unit is the homeomorphic family, whose members are both homologous (evolved from a common ancestor) and homeomorphic (sharing full-length sequence similarity and a common domain architecture). PIRSF families are cura...
متن کاملThe HMG-1 box protein family: classification and functional relationships.
The abundant and highly-conserved nucleoproteins comprising the high mobility group-1/2 (HMG-1/2) family contains two homologous basic domains of about 75 amino acids. These basic domains, termed HMG-1 boxes, are highly structured and facilitate HMG-DNA interactions. Many proteins that regulate various cellular functions involving DNA binding and whose target DNA sequences share common structur...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Computational Biology and Chemistry
سال: 2003
ISSN: 1476-9271
DOI: 10.1016/s1476-9271(02)00098-1